Catalog No: CY5546 Reactivity: Human Mouse Rat
Isotype: Rabbit IgG Applications: WB ICC/IF FC

UniProt ID: Q13501
All Names: OSIL; Oxidative stress induced like; p60; p62; p62B; Paget disease of bone 3;PDB 3; PDB3;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 62 kDa

WB: 1:5000~1:10000
ICC/IF: 1:50~1:200
FC: 1:50

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier
of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitincontaining
bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic
machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve
growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May
regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and
CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of

K+ channels.
 

Western blot analysis of p62/SQSTM1 expression in SKBR-3 cell lysate.